Thanksgiving is one of the busiest travel periods of the year. Remember that with the increase in holiday traffic the law enforcement agencies will be doing their best to keep the roads safe. See "State police to increase patrols for holiday" by the Waldo Village Soup. (Hint: keep your speeds down).
The Maine State Government has sent out a safety message entitled "Enjoy Thanksgiving Safely". It also has a "Turkey Day Safety Fact Sheet".
And if you are NOT traveling and are preparing your turkey meal at home then here is some safety advice available from the University of Maine Cooperative Extension on "Helpful Hints on Handling Turkeys for Thanksgiving".